MissOPTIMA

Missing Outcome data in Psychiatric Trials & Meta-Analysis

Here is some suggested reading about the impact of missing outcome data in meta-analysis

Higgins JPT, Altman DG, Sterne JAC. Assessing risk of bias in included studies. In: Higgins J. P. T., Hollis S (eds) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011: 2011.

Juni P, Egger M. Commentary: Empirical evidence of attrition bias in clinical trials. Int.J.Epidemiol. 2005; 34(1):87-88. 3. SAGE Publications, Inc. Attrition Bias. Encyclopedia of Measurement and Statistics. SAGE Publications, Inc. 2007.

White IR, Higgins JPT, Wood AM. Allowing for uncertainty due to missing data in meta-analysis--part 1: two-stage methods. Stat Med 2008;27(5):711-27.

Altman DG, Bland JM. Missing data. BMJ 2007;334(7590):424.

Groenwold RH, Donders AR, Roes KC, Harrell FE, Jr., Moons KG. Dealing with missing outcome data in randomized trials and observational studies. Am J Epidemiol 2012;175(3):210-7.

Higgins JPT, White IR, Wood AM. Imputation methods for missing outcome data in meta-analysis of clinical trials. Clin Trials 2008;5(3):225-39.

Higgins JPT, Green S, (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration; 2011. Available at www.cochrane-handbook.org

Mallinckrodt CH, Watkin JG, Molenberghs G, Carroll RJ. Choice of the primary analysis in longitudinal clinical trials. Pharmaceut Statist 2004;3(3):161-9.

Gamble C, Hollis S. Uncertainty method improved on best-worst case analysis in a binary meta-analysis. J Clin Epidemiol 2005;58(6):579-88.

White IR, Welton NJ, Wood AM, Ades AE, Higgins JPT. Allowing for uncertainty due to missing data in meta-analysis--part 2: hierarchical models. Stat Med 2008;27(5):728-45.

Altman DG. Missing outcomes in randomized trials: addressing the dilemma. Open Med 2009;3(2):e51-e53.

Mallinckrod CH, Lane PW, Schnell D, Peng Y, Mancuso JP. Recommendations for the Primary Analysis of Continuous Endpoints in Longitudinal Clinical Trials. Drug Information Journal 2008;42(4):303-19.

Hollis S. A graphical sensitivity analysis for clinical trials with non-ignorable missing binary outcome. Stat Med 2002; 21(24): 3823–34.

Panel on Handling Missing Data in Clinical Trials, National Research Council. ‘Front Matter’. The Prevention and Treatment of Missing Data in Clinical Trials. The National Academies Press, Washington, DC, 2010.